C4D generally runs within a VMware image but the 3D emulation with VMware is not very advanced and quite limited in performance. While it's ok for general purpose modeling and animation, it doesn't have direct GPU access nor CUDA / OpenCL support. So for example GPU viewport tesselation, GPU based TFD simulation or CUDA mode in renderers like Vray or Cycles4D will not work.
Edit: I noticed you mentioned VMware v5 / v7, so I guess this is VMware Fusion for Mac? The current VMware version for Windows is 12.5.